Up until not that long ago, I was required to administer a handgun course that included a 50-yard line. I listened to a lot of excuses as to why the 50 was the primary reason for low scores. Some of those excuses included 45ACP bullet drop at that distance. After shooting a variety of 45 pistols carried by those who levied that excuse, I concluded that dipping, jerking, flinching, improper sight picture, etc, was the problem, not the pistol or bullet. My own experience with Glock 21s and M&P 45s reinforced my views that that ther is no significant drop beyond 25 when I was shooting qualification scores of 95-100 percent consistently. I have fired from that distance using the "problem" guns (Glock 30, chopped versions of the Sig 220, etc), and while some of them were not my first choice for carry, were not as inaccurate as was claimed. The only true way to see if a specific load has any significant loss of trajectory at distance is from a vise. Incidentally, I've dealt with the same excuses when shooting 2 inch J frames with wadcutter at greater distances, and even a Model 60 is more accurate at 50 yards that many will give credit - that without a vise.