In MY considered opinion...Yes...but no.
Back in the day, John Linebaugh had some real interesting load data for the Model 25 S&W, which was one of his most often carried guns. According to him, a S&W was no more likely to experience a catastrophic failure than a Ruger Blackhawk. But those hot loads in the Smith would create frame stretch and knock a gun out of time in fairly short order, so the tier 3 loads were to be shot rarely and judiciously. When I was younger and dumber, I put a few hundred of those kind of loads through my Mountain Gun. the gun never showed excessive signs of wear, and needless to say, I've retained all my digits.
BUT...That Linebaugh article has long since disappeared from the internet. there just might be a good reason for that.
Now, this is just my judgement talking...
Here in Alaska people have deadly confrontations with grizzly and brown bear every Summer. the first Summer I was here, in the early 90's a guy died from a bear attack. he was...like us, into his guns, reloading, etc. He had a Freedom Arms as I recall. The bear attacked, he fired a round that did not stop it and then the gun malfunctioned. as I recall a bullet jumped crimp, and he died with an exquisite revolver filled with custom handloads nearby.
My point is that I don't believe in "red lining" our revolvers, or ourselves. find an upper/middle of the road load that you can recover from, and stop. you won't have over expanded brass, bullets jumping crimp, excessively hard magnum primers, slow follow up shots. I'd rather have a cylinder full of 255 grain SWCs that I can reliably put on target than a cylinder of 360 grain bullets that I might be able to process and put on target.
Additionally, I don't think there is a blackie in existence that can't be taken out by a well placed 255 grain SWC.
In summary, COULD your buddy run those hot whale-a-gator monster loads? Probably.
SHOULD he? absolutely not.
Stay in the safe mid range, and avoid catastrophe. We typically carry these guns because we don't wanna take chances. not because we want to increase them.
Incidentally, it's this back and forth on the strength of the S&W that lead to my picking up a Ruger Redhawk in .45 Colt just yesterday.