I have 2 Dillon SDB, and die sets (mounted on change kits) for .38, .380, 9mm, .40, .45. To be practical, you have to buy the change kits so you can change dies en bloc with adjustments intact. Say 10 minutes to change calibers, plus I take the opportunity to clean for another 10 minutes. Also as a practical matter, I have an additional primer assembly set up for large primers, so I can change the entire primer assembly and not fiddle with the set screws to switch an assembly between small and large primer carriers. Basically I don't have to adjust anything except the powder measure, unless I switch to a different bullet, then I adjust seating die.
I shoot a lot of ammo in practice and competition, and have essentially worn out one of the SDB presses, but because DIllon gives me the necessary parts to maintain the press, it works like new. I even wore out the main wave bearings and the brass wheel that operates the primer carrier, but they sent me new parts free. It really is a "no BS" guarantee.
The SDB loads pistol ammunition that is the equal of any loader, single stage or progressive. It does not load rifle ammo. The dies are proprietary to the SDB (won't take standard dies) and they are very good dies, especially suited to progressive loading. If using standard dies is important to you, move up to the 650. Had I known I would be loading tens of thousands of rounds a year, I would have just bought a 650 to start with: the 650 is faster, the change kits are a little cheaper and easier, and it uses component feeders. The difference is not worth switching to me since I already have the SDBs. More like good and better, not anything really wrong with either.
I can run 100 cartridges in 12 minutes, but by the time you add in reloading the primer feeder, checking the powder hopper and generally getting bullets and brass in position, I can run about 300 cartridges an hour, and how many hours you can run depends on you. I can run 1000 in one day, but I don't usually load that long.
I'm familiar with tools and can follow directiions OK, and I find it simple to take an SDB apart, even stripping it all the way down for infrequent major maintenance and parts replacement. They stay mounted to the bench, and require only a box wrench and 4 allen wrenches to maintain. Cleaning out the primer dust from the used primers is the most frequent task, and is convneient to do when changing calibers.
If you have any other questions, feel free to ask.