4227 is a good powder in .357 , and magnum-ish revolver ctgs generally. The max loads will be somewhat slower than 2400 or 296 , but still magnum class. Not withstanding the light bullet/ heavy bullet , fast powder/ slow powder dolklore , I have used 4227 with 125 jacketed in .357 , and gotten sub 1in groups @ 25yds.
If one is conversent and comfortable to discuss load density , I have a prefered aproach to initial load , that usually works well enough to declare sucuess. - More or less standard wt bullet for the cal , 90-95% load density of 4227 . No hard and fast rule on primers. Near 100% loads with std to heavy bullets usually work fine with standard primers. if showing signs of inconsistant ignition ( typically lighter bullets , or low end loads ) they try magnum primer to see if helps.
Oh , it will be accused of being "dirty" . Just clean your revolver every 2-300 rounds , and enjoy the accurate , and reasonably powerful loads.
