There was a discussion about it already and nobody gave clear answer.
Yes, you can swap slides between Shield M2.0 and Shield Plus. You can rack it, load to the chamber, eject without single issue.
But that was the max that anyone went so far.
I'm not sure what would be bad if striker hits the primer properly. To test it, you can use laser cartridge and see if does it work. If yes, you may try to fire the live round...and be the first person who make it.