Today I went to the range and one of the revolvers I was shooting has both 22 LR and 22 mag cylinders. After 50 rounds of 22 LR I noticed I had the mag cylinder in the revolver. The cases were slightly bulged but not enough I noticed on extraction and no change in accuracy. I probably had a slight carbon ring in the chamber like shooting 38 Special in a 357 but otherwise no harm that I can see. Do you see any long term negatives to shooting LR in a mag cylinder?