One thing to consider is that replacing a slide means you're also replacing the manual safety/decocking assembly, which is what indexes off the frame's sear release lever and controls the decocking 'timing'. Keeping the decocking timing within normal factory spec is important. For example, you don't want the hammer falling too soon ... or not falling when the decocking lever is at the end of its arc.
BMCM has a thread where he discusses the way the decocking timing is checked (and how a new lever is fitted), etc.
Also, in the aluminum frames replacing the original barrel may mean the frame wear in the camming shoulders may be different. You don't want any roughness (manually cycling the slide) in unlocking/locking caused by the barrel's camming shoulder cuts not smoothly moving up and down the frame's corresponding camming shoulders.