From reading my reloading data, generally, for the same bullet type and differing weights, the higher the weight of the bullet, the lower the charge of powder, because the heavier bullet has more mass and therefore more inertia, and so takes more time to get moving than a lighter bullet, and therefore the pressure will be maintained with a heavier bullet.
For example, I load my 240gr LSWC bullets with 18.5gr of 2400 powder, and that's the lowest listed in my Lyman 49th manual--it's definitely a magnum load, but not near as atomic as some I've shot. If I were to go with a 250gr LSWC bullet, I'd probably start a little lower. I don't know how much lower, but I'm certain that 18.5gr behind the 250 would still be a medium-strength magnum load.
As for the other powders you've listed, I don't have any experience with them...
When enough is enough? When the bullet does what you want it to do. For me, the 18.5gr 2400 is plenty; I don't hunt, I just like punch paper and to beat up my hands occasionally. I'll bet it could do a good amount of damage against an animal, but maybe not as much as a heavier charge of that powder, or perhaps a different powder with different burn characteristics (the H110 you have listed is supposed to be slower than the 2400, and so requires the use of a magnum primer to light it off...it burns longer and develops more pressure and so more velocity), or perhaps with a different bullet (I might be looking at a heavier bullet for more penetration...not really applicable against a paper target). If you stay within load specs in the manual (especially a modern one that's been lawyer-ized), you should be OK.