My standard load for the .45 Colt has always been 9 grains of Unique under a swaged Remington 250-grain RNFP. I shot these for many years through a Ruger Blackhawk and a Colt Anaconda. I wonder if this is OK in my new 25-15 or should I drop the powder weight a couple grains? I did put a cylinder's worth of these cartridges through it and found that my crimp needed to be heavier to keep the bullet from backing out, a problem I never had with the other two guns. I think part of it might be that the Smith is lighter and recoil is snappier. Shooting the 25-15 is a pleasure and I don't want to stress it.