While I am a big fan of +P ammo in .38 Spl caliber and used it for SD when I carried a M60 for many years, I don't use +P in most other calibers - especially 45acp. The reason is I don't carry a 1911 or other 45 acp for SD and so I just don't need it. While +P ammo will not blow up a gun in good operating condition, the more powerful the load is, the faster wear will be accelerated, the greater the recoil, the louder the report and usually you will get more muzzle blast.
In the case of a 45 acp for SD, the 45 acp 230 grain FMJ has a very good track record for a non +P, non expanding bullet. IMHO, a FMJ bullet will feed better than ay other configuration and therefore would be the most reliable. That is just my two cents....... YMMV.