The 475 Linebaugh and 475 Maximum, along with the 480 Ruger, could be shot from a proper 5-shot X-frame and would be the trifecta of excellence only provided by Smith and Wesson.
If you wanted to start with a 460 you could replace or ream and rerifle the barrel to .475 and ream the cylinder. But it would be a down grade as far as power goes.