I know that the diameter of cylinder throats has been discussed a lot and seems to be an ongoing concern for a lot of people. Myself included.
But, for the heck of it, I carefully measured the cylinder throats on all of my Smith revolvers from several eras. I used a set of very expensive pin gauges that I picked up in my travels at some point.
To make a long story short. My .45 ACP Model 25-2 from the seventies does not have two cylinder throats the same size. All too big. At least one is way too big. The gun is a tack driver.
I did the same with my stainless .45 ACP Model 625-6 (Model of 1989) has cylinder throats that are the perfect size. No deviation between the cylinders. All the correct size. It is one of the poorest shooting guns that I own.
I should add that I did not shoot any lead in either gun for my tests. All high quality jacketed factory stuff from various makers. Lead bullets might perform differently. Didn't test any so I can't say.
So, if it is any consolation, my very unscientific tests tell me that there is more to revolver accuracy than the size of the cylinder throats. All other things being up to snuff, it may not be a big deal. If it is possible to somehow get some test ammo, you might find that the gun shoots fine. As has been said, the target will tell you once and for all.