When a gun is forged, the molecules are aligned in a certain way which gives it its great strength. A bunch of things happen over time.
1) There is something called metal fatigue that weakens the metal over time.
2) There is wear, stress and stretching of the tolerances from being fired - the more it is fired, the more distortion there is.
3) In the real world the formula for the powder will likely have changed, and so will the make-up of the components in the ammunition.
4) There will be new developments in metallurgy resulting in smaller, lighter weight guns with metals and or polymer combinations that have greater strength than what is currently available.
5) That is why ammo makers are very cautious to "dumb-down" ammo to be safe with older and tired guns. Unfortunately, when you do have a modern gun of great strength, a lot of the ammo that is available is not up to the potential of the gun you shoot it out of. That is exactly why Companies like Buffalo Bore, Speer, etc. have such a great following. Their stuff is just so much better than the products that are available form the "Big Three" ammo Companies (for the most part).
Don't worry too much, because UNFORTUNATELY I doubt the public will be allowed to own forearms in 100 years (probably a lot sooner) so the metal fatigue and powder developments will be a moot point. By the way, I hope I am wrong about this statement!
Chief38