I'm not a ballistics expert....nor did I stay at a Holiday Inn Express last night. That being said, I have always adhered to published reloading data. I'm not qualified to say what will and will not happen when you diverge from published data.
Years back when I reloaded .357 Magnum cartridges with 2400, I observed that, even with magnum primers, 2400 did not burn completely when shot from a 4 inch barrel. Occasionally some un-burned granules worked their way beneath the extractor star and impeded cylinder rotation and actuation.
This is just a "SWAG", but without the magnum primers you may experience the same problem. Others may know more though.
JM2C.
JPJ