Well, BUFF, I don't usually carry a .25, because I have a lot of other stuff to choose from...but I see that you are LEO like myself, and I know that I've seen a quite a few of dead folks that got that way with a .25.
I'll agree, and I have the utmost respect for the Colonel, and have studied his works quite a bit, but....I would rather have a .25 than nothing, or even a hatchet!
Shot placement is very critical, and my own observations of dead folks with .25 cal holes in them confirm that the bullet striking something critical was the deciding factor.
On the other hand, I always like to point to another shooting victim that I know of, locally, who was shot through the torso with a .44 mag, and not only survived, but was back to work in a month or so. Why?....Nothing critical was destroyed, and prompt medical intervention helped stabilize the victim
Point is, that the little .22s and .25s are frequently underrated. Same thing with the .32. At one time it (the .32) was standard police issue in most European countries in the ACP form, and in many US police Departments in revolvers. Teddy Roosevelt, when he was Commissioner of the NYPD, chose the Colt .32 New Police as the first issue gun for the department, and issued thousands of them.
Best Regards, Les