I am pretty high risk, and getting worse. I have two specialists. I have trusted them for several years with various aspects of my treatment for the underlying stuff. They are both pro vax, and told me to get it ASAP. I had to fight to get it; according the docs and my employer, I should have been able to get it sooner than I did. The state folks were a PITA about it. Was I nervous? Yup. Even though I was not completely confident in the vax, it was far less risky than doing without.
I'll admit that I am a major needle sissy. Hate the jab, no matter the source, type of shot, whatever. Tough. I suck it up. I even give myself one of my regular shots. I dislike masks. Years in LE tells me that someone in a mask needs to be addressed at gunpoint, a reflex I have had to overcome. Considering that it is pretty likely than the main mode of transmission is airborne, masking is a BFD in terms of protection. (Turns out that the original understanding of the size of transmittable disease molecules is far smaller than the 1950s research indicated, due to a math error back then.) I also hate being told what to do. I sucked it up, got as much info as I could, and made my decision.
My wife and I are not very social, so the isolation made no measurable difference in our lives. I had to work, as my whole office is "essential"; I did not work from home because I knew I would be unproductive. I was one of 2 or 3 in my division instead of the usual 6. (Best. Year. Ever.)
I urge everyone to have a real down and dirty chat with your medical providers about the vax. Even thought it is not perfect and not completely proven, for the overwhelming majority (99% or so), it is safer than the infection. In addition, the less transmission we have, the less mutation, which is a Real Big Deal.