I reload 38 spl and 45long colt.
Both are large cases.
Does anyone have any experience using over powder wads?
Besides Trail Boss, what powders are bulky enough to fill the case more than 1/4 full?
Both are forgiving cases with lower density loads, but stay within the recommended load ranges, in other words, not below the lowest posted data.
Power Pistol is an excellent powder for .38 Spl., with a wide range of loads for several bullet weights. I load 125 and 158 grain JHP's or flat-nose plated bullets. 5.5 grains PP will drive a 125 grain to a tad over 800 fps, and 7.1 grains is a +P load around 1050 fps. For 158's, PP at 4.5 grains is a tad over 600 fps, and 6 grains is a +P load, about 850 fps.
What do you shoot .45 Colt in? Something like a SAA, or M25 S&W, or a heavier framed gun like a Ruger Blackhawk or Thompson Contender? The SAA and M25 won't handle the higher end of .45 Colt loads, keep the MV around 800-850 fps tops. Again, Power Pistol works well in the .45 Colt case, but an 850 fps load for a 250 grain round nose flat point plated bullet, (8.7 grains) barely half fills the case. Accurate #5 takes 10.4 grains to give the same velocity, so it will take up a tad more room in the case. The big 250 grain bullet does take up some room, as it seats pretty deep.
I shoot .38Spl. in four S&W's, all .357 magnum guns, 2 K frame and 2 N frame, and generally load mine to +P levels. I shoot .45 Colt in a S&W M25-5 and have no problems with any of the stated loads, which I use straight from the Hornady 10th edition manual. I don't use any filler in the cases, no dacron plugs, etc.