If I have color on my sights, I only want it on the front sight. I too bought into the night sight business, for a time. I did not find them to be really helpful back when I could still see well. These days, I generally use a dab of green paint on my front sight which allows me to know for certain that my front sight is positioned "on" the target. If I am able to hold my gun in my normal way, I am going to be looking down the top of the frame or slide at that front sight. And these days, for the kind of shooting I mostly do, I don't have to have a crisp focus on that front sight. I do, however, wish to have that front sight in my field of view while looking down that frame or slide as a point of reference. We all know that we don't always have the opportunity to take our normal "hold" and stance. In those cases, we do the best we can. That's when, for me, I take comfort in having the option of my CT laser dot available.
There is a lot more I could say about what works for me, but with respect to the question here, I want my rear sight to be black, with any color present to be only on the front sight. And the dab of florescent green paint on my front sight works as well for me as anything, day or night. That makes a good point of reference and keeps me as focused on where my front sight is as anything I've tried. I've spent a lot of time over the years learning to use my body to keep my windage close to right. But it all depends on how much distance is involved and how alert I am to the need for pointing (aiming) my gun.
FWIW, I also found in my case that if a serious threat presents itself, even with some experience dealing with those, it is VERY hard not to be focused on the threat (the gun, the knife, what ever it is that will hurt me bad!) instead of firmly and clearly on my front sight. That's just human nature, at least for me! But if I can recognize where my front sight is within that picture, I can at least have a pretty good idea where my round will land. This is about the best I can do at this time in my life with the abilities and skills I possess (in diminishing capacities!).