Firearms are like golf clubs..... you have to pick the correct one for the job at hand.
What is the difference between a 6-iron and an 5-iron? I have no idea.
Now the difference between a 22-250 bolt and a 243 bolt
The .243 is for coyotes @ 200-yards.
The .22-250 is for coyotes @ 180 yards.
Same logic with .22 Revolvers:
The 2" revolver is for shooting shotshells at neighbor's dog @ 20 feet.
The 6" revolver is for shooting real bullets into skunks @ 20 yards.
I know lots of golfers that have more than one set of clubs.
I also know lots of us that have more than one set of guns.
Now, what was the question?
What is the difference between a 6-iron and an 5-iron? I have no idea.
Now the difference between a 22-250 bolt and a 243 bolt
The .243 is for coyotes @ 200-yards.
The .22-250 is for coyotes @ 180 yards.
Same logic with .22 Revolvers:
The 2" revolver is for shooting shotshells at neighbor's dog @ 20 feet.
The 6" revolver is for shooting real bullets into skunks @ 20 yards.
I know lots of golfers that have more than one set of clubs.
I also know lots of us that have more than one set of guns.

Now, what was the question?