Jumped crimp caused total lockup after the first round. Eastern European ammo.
My experience has been that while revolvers tend to be very reliable, when they do fail it is difficult to get them back into operation quickly. The most common failure for me has been the ejector rod unscrewing and debris getting under the extractor star, binding up the cylinder.
When an auto malfunction, usually it is easily cleared by manually cycling the slide and ejecting the problem cartridge. Most auto malfunctions are due to magazines.
I was shooting my 625 in a IPSC match and had the cylinder fall off during a reload. It seems the crane retaining screw had backed out allowing the cylinder assembly to fall out.... imagine my surprise. Totally avoidable failure but a failure nonetheless.
I had one once where what they simply call the "bolt" that the cylinder release thumb piece operates, failed and completely disabled the revolver. The "block" piece of the bolt that pushes the cylinder pin forward when trying to open the cylinder, broke off from the rest of it, meaning the cylinder could not be opened, and the broken piece then fell down in the hammer area, blocking the hammer out, so no cocking possible and no DA or SA trigger function remained. A complete stoppage of use.
Side plate had to be removed to diagnose and unjam the works and manually push the pin to open the cylinder to remove live rounds. These were mild loaded HB wadcutters and the gun shows very little signs of firing in its time (actually an early 1970's gun).
Luckily this happened on the range. Close examination of the part showed the block part was apparently defective, only barely attached to the rest of the part in a small area, and that junction failed.
Additional issue - bottom of jaw was bruised when it hit the ground.
A Sheriff once told me he would "rather have six for sure than fifteen maybe."
While we all admire the high reliability of the six gun, I am just wondering what revolver failure experiences may be out there? (not including any internal lock related failures please).