I hav a colt .38 ds and I use the 147 hydra shok in it that is my preferred load, I love this load with my colt infact i hav a springfield 40 xd and when it comes to accurate shooting at a distance I'll shoot my colt with this load everytime, But you have to be the judge on using this load. My thoughts are federal would not have made this load for .38's if it was not safe to shoot in 38's. Just my two cents