For personal carry, I prefer revolvers, especially an airweight J-frame, like a Model 38 or 638 for pocket carry. For inside the house, especially at night, my choice was a S&W M&P 40c equipped with combination fiber optic / night sights, Crimson Trace laser grips, and a S&W Micro 90 flashlight. I also use the full sized magazine, rather than the compact one for increased ammunition availability. To me, this about as good as it gets for a home defense handgun.
Regards,
Dave