There's not much difference in keeping one in the chamber on a semi auto as there is in keeping a revolver around.
Do you still have the strength in your hand to pull a DA revolver trigger?
If that's for me, yes-no problem at all. Moreover, most autos I can rack the slide ok. It's just a couple I have that are more difficult. I thing one of the problems with the Commander is I put an EGW fps and honed a small radius on it and replaced the factory stop with this one. It takes a bit more strength to pull the slide back due to that one modification but, I sure don't have to worry about the extractor clocking and it gives the slide a bit more time to slow down so the magazine rounds can catch up...no more slide outrunning the mag.