Well, in the 44 mag, the cartridge which I most often load heavy for caliber bullets in, I can get 1350 fps or so with a 300 grain hard cast, depending on barrel length. That said, I have been handgun hunting for about 30 years, and have found that a 300 grain, hard cast bullet with a large flat nose, or of the sharp shouldered Keith design at about 1000 fps is a lot easier to shoot, and will do a complete pass thru on deer and hog size game. Leaves a good blood trail, and they usually run 20 or 30 yards, and fall dead. I am not convinced the extra bullet energy of a faster heavy bullet makes any real difference, as you are not looking for expansion, and already have complete penetration.