Only two N frames I have at the moment are a 625-6 Mountain Gun and 25-13 Mountain Gun, both in 45LC, and I don't feel undergunned with either one. In fact either of them will probably be used as carry guns now that the weather allows me to wear a heavier coat.
Now if I can just afford to get a 44Sp to add to the collection.
I'm a Senior Deputy and was having trouble handling 1911 jams so started carrying a 25-14 Lew Horton 3" barreled N frame. I qualify and carry it on duty. I can give 1911 users a run for their money on quick reloads using RIMZ speed clips. I get a lot of attention during qualifications. I can shoot .45Rim or Auto with clips.
It's a good one!
If I could only have one N frame it would be one I don't have, a 5" gun and it would be blue. The caliber is up in the air a little, especially if both my wife and I used the gun. I would probably go for a .44 mag, but the .357 is a possibility.