I am a lefty as well, and sometimes think it has advantages, such as hitting a mag release with my middle finger and never having to adjust or readjust my grip to do it, and dumping empties from a revolver and reloading, especially with a S&W revolver, it seems totally natural to hit the thumbpiece with my left thumb as I push the cylinder open with my right thumb and push the ejector with my right index finger, then reload with my dominant hand, since you are now grasping the gun with your right hand, as far as safeties, I guess when you do it backwards from day one, it doesn't seem backwards, even a semi auto pistol, I have always used my trigger finger to operate them, slide or frame mounted....