Reduced 500 loads
To date, the only bullet I've used in my 500, no matter what the power level, has been the Hornady 300 FTX. My light load with 2400 is 23.0gr. having a volume density of 68%. With Unique it's 12.5gr. having 59% VMD. (Be mindful of the possiblity of double powder loads.) Both are ~950-1000fps.
Pressure wise, neither of these need rifle primers. I used CCI300 only in that Unique load, & without issue. (My max. though, with Unique, was 19.0gr which is ~43K psi.) If you do substitute primers you need to look closely at the first fired primers to see if they're getting pierced. Not because of pressure but the hammer strength/firing pin length may be too hard/long for the slightly thinner pistol primer's metal. The 500 did not have this issue (neither did my 454 Casull) but my 460 does & so I don't use them in it for reduced loads. Pistol primers are also slightly shorter, height wise, by about .0085" (.1200" vs .1285", CCI300 vs CCI200).
Hope your back gets better soon!
.