A lot of good points already made. One thing about leather, if you live in an area that gets even a little hot in the summer, sweat. I don't sweat bad and still if I wear all day the leather gets soaked. I then have to ensure the holster is dry for the next day. If you don't plan on wearing all day, or are in an air conditioned environment it isn't an issue. I avoided kydex for a long time because I just assumed it would be uncomfortable IWB. Turns out for me it is a non-issue. I prefer kydex for comfort.
I also find that belt loops/clips on both sides of the holster, as opposed to on top of it, are more comfortable and more importantly conceal better for me.
And as others have said, you will likely end up trying at least two or three different holsters before you settle on one.
Good luck in your search.