Yes many 10mm enthusiasts are saddened by Smith & Wesson's dropping the 10mm guns, I would bet the 10mm would still outsell the 460's or 500's...
I know that 10mm enthusiast are just chomping at the bit for the next and best innovation pistol made, that can handle the potent 10mm cartridge ballistics.
To have S&W develop the M&P 10mm would be nice and I had stated that it being made as a Custom Package with conversion barrels would add to its flexibility. My interest would be the 10mm M&P 6" slide and barrel, with 40S&W, 357Sig and 9x25Dillon conversion barrels, as something I'd be into.
I know this flexibility from my S&W1006 with Bar-Sto conversion barrels for 40S&W and 9x25Dillon already.