I consider them approximately equivalent, and believe that the three main differences are DA trigger pull, fit to your hand, and accuracy of the individual sample that you have in your hand.
The DA trigger pull of the Colt definitely stacks. Whether this is good or bad is a personal judgment that may depend on your hand size and the use to which you put the gun. All I can say is that you will not be surprised when you shoot someone or something with DA on a Colt. It could conceivably happen with an S&W. For best accuracy, one is about as good as the other SA, if you leave that capability on the gun.
Fit of gun to hand varies with hand size. For my hand, the older Colt Cobra, unshrouded, comes with stock grips that combine with a Tyler to be slightly better than an RB 12 with Tyler, which is somewhat better than an SB 12 with a Tyler. YMMV.
I own three Colt 2" D frame revolvers (old DS, old Agent, old Cobra), and none of them is particularly accurate. Both of my 12s are better, and my 2" 15 is significantly better yet. However, I believe that it could have turned out almost the opposite. I don't own enough 2" medium-frame revolvers, however, to support my belief.