I agree with the other posters that, if at all possible, try to retain that fine .45 Colt revolver.
However, that said, I differ with the other posters regarding the "usefulnesss" of a late S&W Model 625-6 or 625-8 JM Special in .45 ACP. I have shot tens of thousands of these loads in my two 625's. The Model of 1989 625-6 is a 5" and the 625-8 is a 4". They will either regularly group under 1" at 25 yards off a rest. Both have proper dimension cylinder throats (4525" right out of the box.
The .45 ACP is a superior target revolver load. Using light loads in that short case are a "made in heaven" level. Powder position problems when using small charges of fast burning powders (4.0 grs of Bullseye or equivalent) work without issue. My bullet for target loads is the H&G #68 (I cast the Mihec correct copy). This bullet can also be safely driven to 1000 fps for use in the field. My heavy bullet load is a NOE correct version of the Lyman 250 gr. Keith which can be safely driven to 850-900 fps with midrange powders (Unique or Hodgdon's Universal as an example). This velocity equals the old black powder .45 Colt load which would shoot through a horse at 100 yards, to put that in proper perspective.
If you have the proper tools, using steel full moon clips (I use Ranch Products Steel Clips) are quite easy to use. You can load up a bunch of these clips and take them to the range. Then, when you get home, remove them (with the tools) at leisure. I have not found that a big problem, at all.
However, for general range use, the polymer RIMZ clips are easy to load without tools and the RIMZ #25 clips retain the .45 ACP cases good enough for range use. They are made of a carbon fiber material that is stiffer than the "regular" RIMZ clips and retain the loaded rounds, better. I prefer the steel full moon clips for "business use" but freely use the RIMZ clips for general range use.
Another option, of course, is to use Starline .45 Auto Rim cases for general use. They work extremely well and last nearly forever.
The .45 Colt, being an old black powder cartridge, suffers from excess capacity when trying to download for pleasant target loads. When the powder is forward, the velocity is considerably less than back against the primer. This generally leads to less than satisfactory accuracy for target loads.
The S&W in .45 Colt is not the most robust platform for heavy loads but it will do quite nicely with the heavier bullets, as others have mentioned above.
John Linebaugh's information on the .45 Colt is quite helpful to people but the "Ruger Only" loads are JUST for the large frame Rugers.
FWIW
Dale53