Iron,
We have had a few threads here about this, and their are lots more with a search.
As I have posted before, these loads are not going to have a definitive, yes they are safe. About all you can do is the research, and make up your own mind. What I have seen and read is that it seems like the loads that are above saami and somewhere about midway to top end Ruger loads may work out.
Here's the rub, again no definitive yes's or no's published, and you will not see pressure signs on your brass with these type of loads. If you are flattening primers or getting sticky extraction you are likely WAY over what the gun can take.
You're gonna be on your own to keep an eye on what the gun and it's parts are telling you. Did the gun go from zero endshake to a number that can be measured? Is there any peening on the cylinder stop notches or the bolt? Is the forcing cone starting to show signs of wear? And a host of other things.
Higher performance absolutely comes at a price. The trick is to keep track of the price, and decide whether you can live with it. I would also note that with these higher end loads, you are moving your safety margin considerably, and as such will need to really pay attention to your reloading techniques.
Just my opinion, and yes I run my 625 in 45acp pretty hard. You actually have more wiggle room than I do, as your longer case gives you a few more powder choices than me ;^)
Craig