MichiganScott has a point. It's probably best if she picks what she likes.
With that said, unless she plans to train to the point of mastering a SA pistol, I would recommend staying with a revolver due to simplicity and reliability. But, even though I prefer revolvers for the "non-gun" person, J frames aren't the easiest thing to learn to shoot well. Depending on its intended purpose, it may or may not be the best choice. If it's for home protection I'd recommend a K or L frame since they typically have better triggers and being larger, heavier, and having a longer sight radius, they are both easier to shoot accurately and have less recoil. If she plans to carry it then size becomes more of a consideration, so the J frame is not a bad choice. You've also picked a very light weight gun with a fairly heavy trigger pull out of the box. You have a couple of options if you want to stick with the small J fame though. One would be to look at an all steel model such as the 640, 649, etc. Still the same size, but being all steel (SS in this case) they are a little heavier, making them a good bit more comfortable to shoot. If you prefer to stick with the light weight small guns you can easily and affordably change out the grips to something that fits her hand better. A couple of inexpensive options that I find makes the J frames much more comfortable to shoot is the Pachmayr Compac, and the Hogue full size grip for J frames, but there are many options and is a personal matter to find what one likes. A grip that fills the hand better than the factory boot grips will go a long way to making the gun have less perceived recoil.
I can't really recommend a pistol smith because I do all my own, but a good trigger job can significantly improve the quality of the trigger on the J frames, making it both smoother and a little lighter.
Good luck on making your wife happy.