I would echo the comments of mkk41... I live in the Lehigh Valley, it seems to be a popular choice for folks moving from NJ and NY in recent years. I have close access to I78 and the 476 turnpike which make Philadelphia an hour away and NYC about 1.5 to 2 hours away.
Upper Bucks is a fine area with lots of open country but higher cost of living, and as mentioned lower Bucks in getting to be Philadelphia. Points North and a little west of the Lehigh Valley may be a good bet given cost of real estate, taxes and availability of land and the general lifestyle.