My 06 GMC 1/2 ton 4x4 has been nothing but reliable, but with only 90,000 miles, time will tell. My 1995 Ford Ranger was 100% problem free until I blew the motor at 190,000 miles - My fault as I badly over heated it while towing a boat when I knew the belt was slipping.
Had a Nissan 2wd P/U with the 4 cyl. NAPS-Z motor (2 spark plugs per cyl.) Towed a boat with it, revving the motor like a motorcycle, couldn't kill it. Eventually sold it, running good, with about 250,000 miles on it.
Worst ever was a brand new 4wd 1982 Dodge Ramcharger. Seemed like anything that could go wrong did. Dumped it with 35,000 miles on it.
A buddy has a fairly new Toyota Tundra, and I am impressed with it. Probably my next truck.
Larry