The main species involved is the Burmese python, which is either the 3rd or 4th largest snake in the world (I forget which). They can grow to lengths of 24 feet give or take. I used to be involved in a reptile society/rescue organization and we had an 16 foot female, a snake that took at least 2 of us to handle. Luckily she was calm and used to people, but a wild, hungry, 24 foot python is trouble by any definition. (Now if you want to discuss real trouble, what happens when the Reticulated python establishes a wild, breeding population in the Everglades? Why are Retic's even legal to own as a "pet"? They are the longest snake in the world, have extremely unpleasant dispositions, and are 1 of the 2 documented man eaters.)
I don't think hunting them is a very smart idea. Frankly if there is an established breeding population of them already there, I think it would be impossible to kill them all. I doubt they'd manage to kill more than a few.