Its a little hard for me to be too specific, since I don't know how your wife intends to carry a revolver. I have an M442, which, for all practical purposes, is the same gun. Its a great pocket carry gun, and an adequate shooter. If your wife does not intend to pocket carry it, the M642 is the wrong gun. I would suggest looking at a M60, maybe with a 3" barrel. It is a much nicer shooting gun. The M64, and similar K frames, are even better, if the gun fits her hand. It would certainly be good if she could try some guns at a range, before buying. My wife doesn't shoot, but our daughter really enjoys shooting my M60-10, with a 3" barrel. I think that many ladies find the J frame to fit their hand better than the larger frames. But, the heavier models, like the all steel M60's, are much nicer to shoot. This doesn't mean that many gun store salesman wont try to sell her an Airweight model.
rat