If I was the one casting them and knew my alloy, I would shoot several over the chronograph with the same weight of powder, and work up from there. Of course that flies in the face of what I tell others. "Change any component, work the load back up." Better safe than sorry.
Internal ballistics being what they are, for the most part, aren't going to suddenly change because you switched bullets. If you take the same bullet and put less in the case the pressure is going to go down if it isn't already hitting an obstruction. The bearing surface is nearly the same on both, no advantage there. Are they the same hardness? Are they the same size? There are many factors. Each one has a part in the equation.