IMO it will depend mostly at the range you expect to be shooting at. I have J Point reflex sights mounted to 3 of my revolvers and they work very well for me out to about 40 yards where I can shoot a 4 inch or smaller groups provided I have some type of rest.
Once the target gets out to 50 yards or more, I need a scope.
BTW, for the 357 Magnum I consider 4 inches the functional limit for a clean kill on a deer. Fact is that it's slightly marginal on power at longer ranges and spending 8 or 10 hours tracking a wounded animal isn't much fun. It's why most handgun hunters that I know start with the 41 Magnum and go up, raw power does a lot to compensate for a slightly muffed shot.
The problem with any red dot sight is that the dots can cover a rather large area at long range. Yeah, many claim to have 4 MOA dots or even less, however in my experience those claims tend to be a bit optomistic.
Upside to the reflex sights such as my J Point is that it takes very little work to carve a bit of clearance in an off the rack holster and it's quite close to the bore axis so you don't have the convergence issues created by a large offset. Since in Michigan Deer hunting means brush busting it's pretty rare to take any deer more than 40 yards out, so the J Point is nearly ideal.
Upside for a scope is that the variable power offerings allow you to really refine your aim point at long ranges. However, you'll have to give up on any intake of caffiene or the shake will drive you a bit nuts.
Downside for a scope is they can make for a rather heavy package. In addition, you'll find that holsters that can accomidate a scope run to rather high cost. Finally, I would recomend that you supplement the scope with a good rangefinder and take care to acquaint yourself with the changes in POI at various ranges because even the Magnums don't approach the flat shooting characteristics of something like a 308.