I've often popped up on these threads to tout 200g LSWC's in .38 caliber, not as a magic bullet, panacea, or even a best all-purpose solution, but as an option for certain circumstances. For the past 6 years, my home defense situation actually gave me a requirement for a 60 ft. indoor shot, and much of the furniture was leather. If that cowskin is similar to human skin in elasticity and strength, some say that penetrating skin is equivalent to 4 inches of muscle tissue. I also live in an area where a lot of potential BGs are 0% body fat types, fast, muscular, and used to fighting. Also, my rural location made overpenetration a non-issue.
Just a couple of weeks ago, we moved a few miles away, into town, in a home where the layout makes the maximum likely shot no more than 25 feet, and most far closer. Home construction, proximity of neighbors, and angles now make misses and/or overpenetration a significant concern. My 4" Mod. 10 is now loaded with Winchester's version of the FBI load, b/c I haven't gotten my hands on the faster, softer lead Remington version that I covet

If bad times ever come, I like the idea of a soft lead bullet b/c of everything I've read about the wounding effect that it has if bone is struck. Grisly, but real.
I've long feared underpenetration with lighter bullets, but my situation here dictates that I consider something that won't plow thru 6 jugs of water & keep going! The Remington FBI load is one that I've never heard anything bad about, really, so it's my default preference until I experiment with some lighter/faster possibilities to see if I feel they'll be adequate, while being even safer for my neighbors. I'm also tempted by the tumbling possibilities noted with the old, slow 200g "Super Police" load. Many loved it, many have criticized it; I'm truly no expert, but believe it was an old school solution to increase wounding potential without upping velocity & pressure to ensure HP expansion.
All these musings demonstrate things I'm trying to evaluate before I select my own permanent ammo, so I'll now ask the OP: what is your perceived threat, and what situational considerations do you have to take into account? If you live in a crowded apt. building of frame & sheetrock construction, my recommendation will be very different than if you live in a rural area.