Re: OP. There have been many good constructive responses posted in response to your question. As to effectiveness, etc., use .410 loads designed for use in the Governor and you will certainly get better results than if you use some plain Jane .410 load intended for hunting with a 18-26 inch long barrel. For slugs, again use ammunition developed for and intended for use in revolver length barrels. When it comes to .45 Colt and .45 ACP loads, load and fire whatever you want. These rounds have been taking care of business for over 100 years. At HD range, they will be just as effective fired from the Governor. It is probably true that the Governor will not give "target" accuracy on par with that commonly expected from revolvers designed and chambered for specific rounds like the .45 Colt and .45 ACP. And... such accuracy is always nice when one is doing a little bit of target shooting at the range or in the woods/fields. But the Governor is not designed for that purpose. It is designed for SD/HD at limited distances. It will never satisfy the traditionalist or the urban warrior. But for dealing with "things that go bump in the night" it will be just the right tool for the job. In 32 years of marriage, my wife and I have served churches located in some not so nice areas. We've had to deal with attempted break-in's on five separate occasions. I or she used what was available... usually a 12 ga. loaded w/ birdshot. I also once used a M-59 (which at the time I knew was not reliable w/ hollow point ammo), a 6" 28 .357 Magnum (which of course had to long a barrel and was chambered in a caliber that would possibly be to loud if fired in a confined space), a .45 ACP Series 70 Colt (which everyone knows often require work for them to be reliable with hollow point ammo and which have such tiny sight as to make them all but unusable in low light). And, horror or horrors... the revolver that now currently sits on the nightstand is a little 15-3 loaded with 125 gr. jacketed hollow-points... and everyone knows the .38 Special is not really up to dealing with a typical HD/SD situation. But, until I can see a reason to change, that little 15 will sit on the nightstand and be carried by my wife in her knitting bag. And hopefully it will never be needed. But should the need arise, I figure it will do fine even if it is not the first choice of the cognizant. JMHO. Sincerely. brucev.