When and if I get a carry permit, I would expect to put my 649 in my pocket for journeys out of the house, or maybe an old postwar .38 M&P with a two-inch barrel. If I get to the point of really trusting a semiauto, there's a .380 PPK/S that might get some port time.
Around the house the guns available for quick access tend to be a little heavier -- a Brazilian, a "Blood Work" 627, a 696.