We used to do that when hunting with pump guns. After about the 2nd or 3rd one in, we moved up to BB or Buck. Back then we were interested in dropping the errant fox. These days the coyote is prime material. Just critters that seem to be on the bad guy list. The larger sizes tend to carry farther.
About 6 or 8 years ago when the 329 came out I took one to a mid winter camp out and shooting session. I announced I had a new gun then retrieved it from my Jeep. I was very careful, loading it with 3 44 specials and 3 of the 300 grain bear loads.

Then proceeded to shoot the first Special at the big old cottonwood. Then complained about the recoil and fired the 2nd. More complaining. I fired the last Special and said it kicked too much for me. All of it was just bait for the guy who could always do anything better than anyone else. It was kind of fun to watch. He was making fun of me as expected, then touched off one of the full house 300 grain loadings. It hurt him bad, but he had too much pride to stop and besides, he was making fun of me. To his credit or stupidity, he fired the 2nd and 3rd. Then he handed my gun back to me.
I watched him and he went over to the beer cooler, took out a really cold one with his left hand, then walked over to a camp chair and sat down. Only then did he transfer it to his right and opened it with his left. To drink he took it back in his left hand each time.

I got him good! So my professional observer, the just retired detective with 32 years on the force leaned over toward me. He said "um, uh Dick, did I hear a slight difference in report between your loads and Davey's?" Always truthful when I served my purposes, I said "I think so". He understood the drill and appreciated it. Mixing ammo had its purpose.