For home defense a wheel gun is the most reliable but the fewer number of rounds concerns me. In a SD/HD scenario it's probably going to be at night and in the dark. Sure, one or two shots might be the end of it, but if it isn't... reloading a wheel gun in the dark doesn't sound like a road I want to travel. I used to have 940 loaded with Federal 150 gr micro HST's on my bed stand. I still do, but next to it is a Beretta short pull CX4 with a 30 round mag loaded with Federal 124gr HST's. Plus it has a Streamlight TLR-2G that couldn't fit on any wheel gun and is indispensable for any "bump-in-the-night" scenario.
Another thing to keep in mind for home defense is magnums are deafening and will blind you at night. 357's (and up) are therefore out for me. 38 specials have some passable HD loads but 9mm has much better stopping power. Hence, the reason my 940 is still on the bed stand...
Reloading a revolver with a speed loader is done by feel with your eyes always on the threat during the day time. In the dark it's done EXACTLY the same way.
That suggests you're doing it wrong. Google "stress fire revolver reload" and learn what it's about and why it works well for pretty much any revolver/cartridge combination.
If you only shoot .38 Special from a revolver with a full length ejector rod you might also consider the FBI reload. It's slightly faster, but not as positive with the longer and higher pressure .357 Magnum cases that can stick in the cylinders, and it exposes your middle finger to a potentially hot forcing cone.
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In terms of sound levels, a standard pressure .38 will generate about 158 dB at the shooter's ear. In comparison a standard pressure 9mm will develop about 160 dB, and a .357 Magnum will develop about 163 dB.
Since sound energy doubles every 3 dB, the .357 Magnum is twice as loud as the 9mm, or in percentages is 200% as loads as the 9mm. However, that 9mm is still 167% as loud as a standard pressure .38 Special.
For home defense where you expect to shoot inside, a .38 +P revolver load is arguably the sweet spot. Noise/sound energy is primarily an artifact of pressure at the muzzle, or in the case of a revolver also pressure at the cylinder gap.
The .357 Magnum and the standard pressure 9mm both operate at a maximum average pressure of 35,000 psi, thus the relatively high dB produced. In contrast the standard pressure .38 operates at 17,000 psi, less than half the pressure of the .357 Magnum and the .38+ P operates only 3,000 psi higher at 20,000 psi, still well below the .357 Magnum and 9mm.
Consequently, the given terminal effectiveness and noise levels, the .38+P is probably the sweet spot.
As an aside the .45 ACP was favored by tunnel rats in Vietnam as it was both effective and comparatively quiet at 157 dB. It's a much better choice than a 9mm for home defense, from a noise perspective, as it is half as loud as a 9mm in the same barrel length and about 33% quieter than a standard pressure .38 Special.
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If I were going to keep a .357 Magnum beside the bed, I would also have a pair of electronic earmuffs beside the bed as well. They are handy as you can turn the volume up and hear what's happening in another room better than with a naked ear, and if you have to shoot, you've got ear protection.