Lots of good answers there that are very near the mark. Yes, it depends -- but not so much on the pistol but on the 'clocking' of it around the waistbelt, in a holster.
Put your favorite pistol, or any pistol, in your waistband without a holster starting at 3:00. For your hand to insert the pistol into the trousers band naturally, you'll discover that the barrel is pointed roughly straight down. This w/b call zero 'caster'.
Move it 'round to 4:00 and you'll find that the angle has changed; this is about 25 degrees negative caster and the barrel is to the rear. This was used by the Texas Rangers beginning 1905 to conceal their SAAs in the Sunday scabbard better known as the Brill.
The FBI followed the same practice because both groups of gunfighters were required to hide their big guns well back of open coats. These were no longer cowboys. It's not an accident for another reaon, that the FBI and the Rangers used the same angle; they also used the same holsters. Famed Rangers like Trimble carried the Brill, and famed FBI agents like Bryce and Campbell carried the Myres Threepersons with the same angle.
Move the pistol further back towards the spine and you'll end up with a 60 degree angle while you're holding the pistol by its grips; this we call *** ("small of back carry" in censored mode) today.
Move it forward of 3:00, to 2:00, and the muzzle will begin to swing forward to what's known as positive caster; your hand will always fall naturally to the grip. This is the angle that became popular with 'combat' shooters of the '70s because it could also be used as a crossdraw on the opposite side.
1:00 and 12:00 carry is simply stupid so it doesn't matter how well the hand falls to the grip when you shoot yourself
Anyway, because few makers accurately depict on their sites or catalogs, just how each of their holster models carries at an angle, one needs to be VERY careful in making a choice. Making assumptions about this purchase will create a 'box o holsters' for you. Ditto getting the carry HEIGHT wrong; ideally the holster carries your pistol with the knuckle of the second finger just clearing or touching your carry belt when concealed carry.
This height will keep your pistol from being top heavy, and keep the cylinder of a revolver at an ideal location on your torso. This is for concealed of course; specialized carry or cowboy carry has another set of 'rules'/'guidelines'.
This way the choice stops being a 'matter of opinion' but a matter of informed choice instead.
P.S. no pistol carrier you meet will truly know what angle his/her pistol is being carried at. I've been on forums a long time and typically these are simply educated guesses. i will say two things: the first is that one cannot 'feel' a difference in angle of 5 degrees; and the second is that no matter what angle you've been handed, you will move the grip along the belt line until your hand falls naturally to the grip ANWAY.