I got my 10/22 in the late 90s.
Despite decades of handgun use, including competition, I had not had a lot of rifle experience. I am not a hunter, so until that 10/22 I did not even own a rifle.
I got interested in them when they started being accurized to compete in the Sportsman Team Competition series sponsored by Chevy trucks. In reading comparison road tests of the era, the accurized rifles consistently shot sub MOA at 50 yards with target grade ammunition. One of the advantages of these articles was that they tested the rifles with a variety of target ammunition, so one could see which rifle preferred which ammo.
In these comparison tests the Volquartsen/Ruger was always the top gun.
Note: This was before Volquartsen transitioned to using only their own parts for their 10/22 rifles as they do now.
After reading all this I bought a Volquartsen/Ruger 10/22. I had some Federal Gold Medal ammo. This was one of the lower priced target ammunitions available, but still, according to the road tests, capable of sub MOA grouping.
I was very interested to find out if I could get comparable performance. I set up a very steady rest on a windless (the norm here) day. I randomly squeezed off five rounds to properly foul the barrel. Then I squeezed off five as carefully and precisely as I could. The result was sub MOA. I was impressed. I think I still have that target around.
That initial group was no fluke. I found that if I followed the same protocol (stable rest, windless day, concentration on my part) I could replicate that sub MOA performance at will.
I tried a couple of the more expensive ammo brands I had read of in the road tests, and found that my experience reflected what I had read. The more expensive ammo grouped even tighter.
I have since made a couple of modifications to make the rifle more preferable to me, but which have no effect on grouping ability. For me, this rifle is now perfect.
Detractors, of which there seem to be no lack, point out that a 10/22 is not, and never will be, a benchrest competitive rifle. True enough, but benchrest is not the only competition venue, and I look at it as a 'different course/different horses' situation. For .22 rimfire competitive events that require a combination of speed and grouping ability, a customized 10/22 is pretty much the only game in town. (Note: I have not been following the competition, so if there are other rifles now being used in these types of events I am not aware).
They 10/22 may have had humble origins (kind of like the small block Chevy) but it is a seminal design that has gone on to refinement and success that Harry Seyfried and Bill Ruger never envisioned.