The Hornady Defense/Duty line-up appears good overall, getting middling or better results in controlled tests; real-world stats are sparse for this load as it hasn't made in-roads in LE use versus standbys like Speer Gold Dot, Federal HST and Winchester Ranger. This doesn't mean it won't do the job, just that there's less hard data.
Critical Duty is built for LE use and is designed to function barrier blind. Critical Defense is intended for civilian use and is built to function absent barrier issues.
I've shot a lot of both in .357 and think it's an acceptable load but not my first choice. It shoots mid-range hot, not heavy like the classic 125 grain Magnum load; flash, report and recoil are nicely controlled for, but you do know you're shooting a Magnum.
I've put it through several different revolvers and only had problems once -- cratering of the primers related to the firing pin bushing; other Magnum rounds didn't do this in this particular revolver but the Hornady Duty and Defense did, so their pressure might be a bit higher. The same Duty/Defense rounds (from the same batch) had no issue in several other revolvers. Point is, always test your defense ammo in the firearm that will be used.