Over and above reliable penetration and possible expansion, would be reliable operation... which you've called into question
The only way to be sure it will operate reliably, would be to test a volume of it in your specific gun, which leads to a major problem...
The polygonal rifling in a Glock barrel can not run hard cast lead, which is why your owners manual says to not run it. The lead will begin to gum up inside the rifling leading to unexpected high pressure situations. Combine that with Glock's notoriously deep and wide feed ramp causing a partially unsupported chamber, plus a very hot round, and your asking for a situation where your Glock blows up in your hand.
Do a YouTube search for Glock Kaboom and you'll get an idea if what that's like. Aside from a little blood and some burns, you'll have pieces of the gun that fly back towards the direction of your face. I don't want to sound like Ralphie's mother, but you'll shoot your eye out.
A Glock is not the way to go with a cast lead bullet.
However, your instinct to prioritize penetration is spot on because a lot of 380 JHP will expand early and dump too much energy too early and ultimately fail to penetrate enough. With 380 ACP, there are only a very few jacketed hollow points that deliver proper penetration. I strongly recommend Federal Hydra Shok 90 grain as your 380 defense load.
Against a 2 legged predator, with virtually any FMJ or hard cast lead in 380, you'll have an over penetration and a failure to transfer energy unless bone is hit. You could purchase an aftermarket barrel for your Glock that has lands and grooves for rifling, instead of the polygonal rifling, and maybe it will feed reliability, however there’s no point. You're better off with a proven round like Hydra Shok.
+P labels on ammo boxes do a better job at catching ammo shoppers then they do at stopping bad guys, just like with how most fishing lures are designed to catch fisherman at the store and are not designed to catch fish in the water.
Lucky Gunner published all kinds of terminal ballistics test data a while back. Ammo that does well in ballistics gel has proven to do well in real world situations.
https://www.luckygunner.com/labs/self-defense-ammo-ballistic-tests/#380ACP
As you can see by the test results, 380 Hydra Shok is slow to expand, and even failed to expand in gel. In a more dynamic environment like a human body, expansion arguably would be greater.
You can see in the data that virtually every round that did expand in gel, failed to penetrate, or did the bare minimum of 12"