Any caliber can be deadly! The whole concept of shooting a bad guy is to STOP THEM as fast as possible. Stop them from the attack, not necessarily to kill them. Larger calibers, faster bullets, better expansion all contribute to better and faster stops - it's just a percentages game. YES - shot placement is also key! That doesn't mean someone who was shot in a non vital organ area with a .22 short won't die hours later from bleeding out - but the idea is to stop them asap so they don't continue doing harm!
The video was taken down by YT and so I did not view it. Threads like this do come up from time to time and just because bad guys have died from .22, .25, .32, calibers mouse guns does not mean they are prudent to carry in most situations. Their only great attribute is size and light weight IMHO.
I've witnessed terrible accidents where people have walked away while driving cars with no air bags and no seat belts. I have also witnessed people driving new model cars with air bags, seatbelts and other safety equipment that have not fared so well. I've actually got a friend that went down on a motorcycle years back at about 55 mph. Aside from being a bit scraped up and in shock, he walked away. I also had another friend I used to ride with that went down on a motorcycle exiting a parking lot at only 12-15 mph after being cut off by a truck, slid on the road surface, slammed his head into the curb and died hours later. While he was wearing a helmet, it was not a DOT or SNELL rated one and did nothing to protect him. Had he been wearing the proper helmet he would have ridden his bike home!
So back to ballistics..... I want the highest percentage chance of accomplishing what I need to if that situation ever comes up. In my mind, the larger, more powerful guns and calibers give me a better change (percentage wise) than smaller ones. For those who tout how their shot placements are so good, remember, one can NEVER predict what is going to actually happen, when, where or how. While I am a huge proponent of practice and familiarity, we never know quite what the situation will be and how good shot placement we will be able to achieve at that particular second, if your hands are being attacked, have to shoot through a barrier or wall, etc. We just don't know! Yea, a .25 with you all the time beats the 44 mag you left in your safe, but there is a happy medium! While I am certainly not into carrying an L or N frame 357 Magnum (too powerful for populated areas, too heavy and too bulky for EDC / CCW) and I'm not into mouse guns either. I've settled on a 17.6 ounce Sig P365 (9mm) that rides in my pocket or on my hip daily. Never too big or heavy to have to leave home and powerful enough with enough capacity to get the job done if I ever had too. To me a sensible compromise that I have confidence in. I want to minimize the "luck factor".