I assume when you refer to "screws/screwdriver", you are referring to taking off the wheel?
The wheel? Do you mean the cylinder? You need the right screwdriver to adjust the sights, remove the grips, take off the sideplate.
First things first. If you are not a mechanically inclined person, buy a good manual on taking your gun apart. Even if you are mechanically inclined, buy a good manual. If you run across something that you don't understand, look it up on the internet.
I will generally detail strip a gun when I buy it to make sure that everything is where it is supposed to be. At that time, I clean and oil it. I use way too much oil but my guns are out fighting in the desert, they are sitting in my closet.
One thing that I have discovered is that S&W revolvers are far more complex inside than Dan Wesson revolvers so I really don't like taking them apart.
My assorted semi-autos get cleaned when they start malfunctioning which means rarely.
It used to be that when I needed to do a detail cleaning, I'd fill a plastic container with VARSOL, remove the grips and then drop the gun into the VARSOL, put the lid on the container and let it soak overnight. Sadly, VARSOL is no longer available.
I have used carburetor cleaner to spray out guns.